CO2-breathing and piercing polymersomes as tunable and reversible nanocarriers

Despite numerous studies on utilizing polymeric vesicles as nanocapsules, fabrication of tunable molecular pathways on transportable vesicle walls remains challenging. Traditional methods for building penetrated channels on vesicular membrane surface often involve regulating the solvent polarity or...

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Main Authors:	Feng, Anchao, Liang, Jiamei, Ji, Jinzhao, Dou, Jinbo, Wang, Shanfeng, Yuan, Jinying
Format:	Online
Language:	English
Published:	Nature Publishing Group 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810324/

id	pubmed-4810324
recordtype	oai_dc
spelling	pubmed-48103242016-03-29 CO2-breathing and piercing polymersomes as tunable and reversible nanocarriers Feng, Anchao Liang, Jiamei Ji, Jinzhao Dou, Jinbo Wang, Shanfeng Yuan, Jinying Article Despite numerous studies on utilizing polymeric vesicles as nanocapsules, fabrication of tunable molecular pathways on transportable vesicle walls remains challenging. Traditional methods for building penetrated channels on vesicular membrane surface often involve regulating the solvent polarity or photo-cross-linking. Herein, we developed a neat, green approach of stimulation by using CO2 gas as “molecular drill” to pierce macroporous structures on the membrane of polymersomes. By simply introducing CO2/N2 gases into the aqueous solution of self-assemblies without accumulating any byproducts, we observed two processes of polymeric shape transformation: “gas breathing” and “gas piercing.” Moreover, the pathways in terms of dimension and time were found to be adjustable simply by controlling the CO2 stimulation level for different functional encapsulated molecules in accumulation, transport, and releasing. CO2-breathing and piercing of polymersomes offers a promising functionality to tune nanocapsules for encapsulating and releasing fluorescent dyes and bioactive molecules in living systems and also a unique platform to mimic the structural formation of nucleus pore complex and the breathing process in human beings and animals. Nature Publishing Group 2016-03-29 /pmc/articles/PMC4810324/ /pubmed/27020003 http://dx.doi.org/10.1038/srep23624 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Feng, Anchao Liang, Jiamei Ji, Jinzhao Dou, Jinbo Wang, Shanfeng Yuan, Jinying
spellingShingle	Feng, Anchao Liang, Jiamei Ji, Jinzhao Dou, Jinbo Wang, Shanfeng Yuan, Jinying CO2-breathing and piercing polymersomes as tunable and reversible nanocarriers
author_facet	Feng, Anchao Liang, Jiamei Ji, Jinzhao Dou, Jinbo Wang, Shanfeng Yuan, Jinying
author_sort	Feng, Anchao
title	CO2-breathing and piercing polymersomes as tunable and reversible nanocarriers
title_short	CO2-breathing and piercing polymersomes as tunable and reversible nanocarriers
title_full	CO2-breathing and piercing polymersomes as tunable and reversible nanocarriers
title_fullStr	CO2-breathing and piercing polymersomes as tunable and reversible nanocarriers
title_full_unstemmed	CO2-breathing and piercing polymersomes as tunable and reversible nanocarriers
title_sort	co2-breathing and piercing polymersomes as tunable and reversible nanocarriers
description	Despite numerous studies on utilizing polymeric vesicles as nanocapsules, fabrication of tunable molecular pathways on transportable vesicle walls remains challenging. Traditional methods for building penetrated channels on vesicular membrane surface often involve regulating the solvent polarity or photo-cross-linking. Herein, we developed a neat, green approach of stimulation by using CO2 gas as “molecular drill” to pierce macroporous structures on the membrane of polymersomes. By simply introducing CO2/N2 gases into the aqueous solution of self-assemblies without accumulating any byproducts, we observed two processes of polymeric shape transformation: “gas breathing” and “gas piercing.” Moreover, the pathways in terms of dimension and time were found to be adjustable simply by controlling the CO2 stimulation level for different functional encapsulated molecules in accumulation, transport, and releasing. CO2-breathing and piercing of polymersomes offers a promising functionality to tune nanocapsules for encapsulating and releasing fluorescent dyes and bioactive molecules in living systems and also a unique platform to mimic the structural formation of nucleus pore complex and the breathing process in human beings and animals.
publisher	Nature Publishing Group
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810324/
_version_	1613558646868803584

CO2-breathing and piercing polymersomes as tunable and reversible nanocarriers

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