Discovery of Novel Alphacoronaviruses in European Rodents and Shrews

Eight hundred and thirteen European rodents and shrews encompassing seven different species were screened for alphacoronaviruses using PCR detection. Novel alphacoronaviruses were detected in the species Rattus norvegicus, Microtus agrestis, Sorex araneus and Myodes glareolus. These, together with t...

Full description

Bibliographic Details
Main Authors:	Tsoleridis, Theocharis, Onianwa, Okechukwu, Horncastle, Emma, Dayman, Emma, Zhu, Miaoran, Danjittrong, Taechasit, Wachtl, Marta, Behnke, Jerzy M., Chapman, Sarah, Strong, Victoria, Dobbs, Phillipa, Ball, Jonathan K., Tarlinton, Rachael E., McClure, C. Patrick
Format:	Online
Language:	English
Published:	MDPI 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810274/

id	pubmed-4810274
recordtype	oai_dc
spelling	pubmed-48102742016-04-04 Discovery of Novel Alphacoronaviruses in European Rodents and Shrews Tsoleridis, Theocharis Onianwa, Okechukwu Horncastle, Emma Dayman, Emma Zhu, Miaoran Danjittrong, Taechasit Wachtl, Marta Behnke, Jerzy M. Chapman, Sarah Strong, Victoria Dobbs, Phillipa Ball, Jonathan K. Tarlinton, Rachael E. McClure, C. Patrick Communication Eight hundred and thirteen European rodents and shrews encompassing seven different species were screened for alphacoronaviruses using PCR detection. Novel alphacoronaviruses were detected in the species Rattus norvegicus, Microtus agrestis, Sorex araneus and Myodes glareolus. These, together with the recently described Lucheng virus found in China, form a distinct rodent/shrew-specific clade within the coronavirus phylogeny. Across a highly conserved region of the viral polymerase gene, the new members of this clade were up to 22% dissimilar at the nucleotide level to the previously described Lucheng virus. As such they might represent distinct species of alphacoronaviruses. These data greatly extend our knowledge of wildlife reservoirs of alphacoronaviruses. MDPI 2016-03-18 /pmc/articles/PMC4810274/ /pubmed/27102167 http://dx.doi.org/10.3390/v8030084 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Tsoleridis, Theocharis Onianwa, Okechukwu Horncastle, Emma Dayman, Emma Zhu, Miaoran Danjittrong, Taechasit Wachtl, Marta Behnke, Jerzy M. Chapman, Sarah Strong, Victoria Dobbs, Phillipa Ball, Jonathan K. Tarlinton, Rachael E. McClure, C. Patrick
spellingShingle	Tsoleridis, Theocharis Onianwa, Okechukwu Horncastle, Emma Dayman, Emma Zhu, Miaoran Danjittrong, Taechasit Wachtl, Marta Behnke, Jerzy M. Chapman, Sarah Strong, Victoria Dobbs, Phillipa Ball, Jonathan K. Tarlinton, Rachael E. McClure, C. Patrick Discovery of Novel Alphacoronaviruses in European Rodents and Shrews
author_facet	Tsoleridis, Theocharis Onianwa, Okechukwu Horncastle, Emma Dayman, Emma Zhu, Miaoran Danjittrong, Taechasit Wachtl, Marta Behnke, Jerzy M. Chapman, Sarah Strong, Victoria Dobbs, Phillipa Ball, Jonathan K. Tarlinton, Rachael E. McClure, C. Patrick
author_sort	Tsoleridis, Theocharis
title	Discovery of Novel Alphacoronaviruses in European Rodents and Shrews
title_short	Discovery of Novel Alphacoronaviruses in European Rodents and Shrews
title_full	Discovery of Novel Alphacoronaviruses in European Rodents and Shrews
title_fullStr	Discovery of Novel Alphacoronaviruses in European Rodents and Shrews
title_full_unstemmed	Discovery of Novel Alphacoronaviruses in European Rodents and Shrews
title_sort	discovery of novel alphacoronaviruses in european rodents and shrews
description	Eight hundred and thirteen European rodents and shrews encompassing seven different species were screened for alphacoronaviruses using PCR detection. Novel alphacoronaviruses were detected in the species Rattus norvegicus, Microtus agrestis, Sorex araneus and Myodes glareolus. These, together with the recently described Lucheng virus found in China, form a distinct rodent/shrew-specific clade within the coronavirus phylogeny. Across a highly conserved region of the viral polymerase gene, the new members of this clade were up to 22% dissimilar at the nucleotide level to the previously described Lucheng virus. As such they might represent distinct species of alphacoronaviruses. These data greatly extend our knowledge of wildlife reservoirs of alphacoronaviruses.
publisher	MDPI
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810274/
_version_	1613558616985436160

Discovery of Novel Alphacoronaviruses in European Rodents and Shrews

Similar Items