Virus-encoded microRNA contributes to the molecular profile of EBV-positive Burkitt lymphomas

Burkitt lymphoma (BL) is an aggressive neoplasm characterized by consistent morphology and phenotype, typical clinical behavior and distinctive molecular profile. The latter is mostly driven by the MYC over-expression associated with the characteristic translocation (8;14) (q24; q32) or with variant...

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Main Authors:	Piccaluga, Pier Paolo, Navari, Mohsen, De Falco, Giulia, Ambrosio, Maria Raffaella, Lazzi, Stefano, Fuligni, Fabio, Bellan, Cristiana, Rossi, Maura, Sapienza, Maria Rosaria, Laginestra, Maria Antonella, Etebari, Maryam, Rogena, Emily A., Tumwine, Lynnette, Tripodo, Claudio, Gibellini, Davide, Consiglio, Jessica, Croce, Carlo M., Pileri, Stefano A., Leoncini, Lorenzo
Format:	Online
Language:	English
Published:	Impact Journals LLC 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807994/

id	pubmed-4807994
recordtype	oai_dc
spelling	pubmed-48079942016-04-19 Virus-encoded microRNA contributes to the molecular profile of EBV-positive Burkitt lymphomas Piccaluga, Pier Paolo Navari, Mohsen De Falco, Giulia Ambrosio, Maria Raffaella Lazzi, Stefano Fuligni, Fabio Bellan, Cristiana Rossi, Maura Sapienza, Maria Rosaria Laginestra, Maria Antonella Etebari, Maryam Rogena, Emily A. Tumwine, Lynnette Tripodo, Claudio Gibellini, Davide Consiglio, Jessica Croce, Carlo M. Pileri, Stefano A. Leoncini, Lorenzo Research Paper Burkitt lymphoma (BL) is an aggressive neoplasm characterized by consistent morphology and phenotype, typical clinical behavior and distinctive molecular profile. The latter is mostly driven by the MYC over-expression associated with the characteristic translocation (8;14) (q24; q32) or with variant lesions. Additional genetic events can contribute to Burkitt Lymphoma pathobiology and retain clinical significance. A pathogenetic role for Epstein-Barr virus infection in Burkitt lymphomagenesis has been suggested; however, the exact function of the virus is largely unknown. Impact Journals LLC 2015-07-31 /pmc/articles/PMC4807994/ /pubmed/26325594 Text en Copyright: © 2016 Piccaluga et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Piccaluga, Pier Paolo Navari, Mohsen De Falco, Giulia Ambrosio, Maria Raffaella Lazzi, Stefano Fuligni, Fabio Bellan, Cristiana Rossi, Maura Sapienza, Maria Rosaria Laginestra, Maria Antonella Etebari, Maryam Rogena, Emily A. Tumwine, Lynnette Tripodo, Claudio Gibellini, Davide Consiglio, Jessica Croce, Carlo M. Pileri, Stefano A. Leoncini, Lorenzo
spellingShingle	Piccaluga, Pier Paolo Navari, Mohsen De Falco, Giulia Ambrosio, Maria Raffaella Lazzi, Stefano Fuligni, Fabio Bellan, Cristiana Rossi, Maura Sapienza, Maria Rosaria Laginestra, Maria Antonella Etebari, Maryam Rogena, Emily A. Tumwine, Lynnette Tripodo, Claudio Gibellini, Davide Consiglio, Jessica Croce, Carlo M. Pileri, Stefano A. Leoncini, Lorenzo Virus-encoded microRNA contributes to the molecular profile of EBV-positive Burkitt lymphomas
author_facet	Piccaluga, Pier Paolo Navari, Mohsen De Falco, Giulia Ambrosio, Maria Raffaella Lazzi, Stefano Fuligni, Fabio Bellan, Cristiana Rossi, Maura Sapienza, Maria Rosaria Laginestra, Maria Antonella Etebari, Maryam Rogena, Emily A. Tumwine, Lynnette Tripodo, Claudio Gibellini, Davide Consiglio, Jessica Croce, Carlo M. Pileri, Stefano A. Leoncini, Lorenzo
author_sort	Piccaluga, Pier Paolo
title	Virus-encoded microRNA contributes to the molecular profile of EBV-positive Burkitt lymphomas
title_short	Virus-encoded microRNA contributes to the molecular profile of EBV-positive Burkitt lymphomas
title_full	Virus-encoded microRNA contributes to the molecular profile of EBV-positive Burkitt lymphomas
title_fullStr	Virus-encoded microRNA contributes to the molecular profile of EBV-positive Burkitt lymphomas
title_full_unstemmed	Virus-encoded microRNA contributes to the molecular profile of EBV-positive Burkitt lymphomas
title_sort	virus-encoded microrna contributes to the molecular profile of ebv-positive burkitt lymphomas
description	Burkitt lymphoma (BL) is an aggressive neoplasm characterized by consistent morphology and phenotype, typical clinical behavior and distinctive molecular profile. The latter is mostly driven by the MYC over-expression associated with the characteristic translocation (8;14) (q24; q32) or with variant lesions. Additional genetic events can contribute to Burkitt Lymphoma pathobiology and retain clinical significance. A pathogenetic role for Epstein-Barr virus infection in Burkitt lymphomagenesis has been suggested; however, the exact function of the virus is largely unknown.
publisher	Impact Journals LLC
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807994/
_version_	1613557858126790656

Virus-encoded microRNA contributes to the molecular profile of EBV-positive Burkitt lymphomas

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