The role of TRPV1 in the CD4+ T cell-mediated inflammatory response of allergic rhinitis

Transient receptor potential vanilloid 1 (TRPV1), which has been identified as a molecular target for the activation of sensory neurons by various painful stimuli, was reported to regulate the signaling and activation of CD4+ T cells. However, the role of TRPV1 in CD4+ T cell in allergic rhinitis re...

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Main Authors:	Samivel, Ramachandran, Kim, Dae Woo, Son, Hye Ran, Rhee, Yun-Hee, Kim, Eun Hee, Kim, Ji Hye, Bae, Jun-Sang, Chung, Young-Jun, Chung, Phil-Sang, Raz, Eyal, Mo, Ji-Hun
Format:	Online
Language:	English
Published:	Impact Journals LLC 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807989/

id	pubmed-4807989
recordtype	oai_dc
spelling	pubmed-48079892016-04-19 The role of TRPV1 in the CD4+ T cell-mediated inflammatory response of allergic rhinitis Samivel, Ramachandran Kim, Dae Woo Son, Hye Ran Rhee, Yun-Hee Kim, Eun Hee Kim, Ji Hye Bae, Jun-Sang Chung, Young-Jun Chung, Phil-Sang Raz, Eyal Mo, Ji-Hun Research Paper: Immunology Transient receptor potential vanilloid 1 (TRPV1), which has been identified as a molecular target for the activation of sensory neurons by various painful stimuli, was reported to regulate the signaling and activation of CD4+ T cells. However, the role of TRPV1 in CD4+ T cell in allergic rhinitis remains poorly understood. In this study, TRPV1 expression was localized in CD4+ T cells. Both knockout and chemical inhibition of TRPV1 suppressed Th2/Th17 cytokine production in CD4 T cells and Jurkat T cells, respectively, and can suppress T cell receptor signaling pathways including NF-κB, MAP kinase, and NFAT. In TRPV1 knockout allergic rhinitis (AR) mice, eosinophil infiltration, Th2/Th17 cytokines in the nasal mucosa, and total and ova-specific IgE levels in serum decreased, compared with wild-type AR mice. The TRPV1 antagonists, BCTC or theobromine, showed similar inhibitory immunologic effects on AR mice models. In addition, the number of TRPV1+/CD4+ inflammatory cells increased in the nasal mucosa of patients with AR, compared with that of control subjects. Thus, TRPV1 activation on CD4+ T cells is involved in T cell receptor signaling, and it could be a novel therapeutic target in AR. Impact Journals LLC 2015-12-18 /pmc/articles/PMC4807989/ /pubmed/26700618 Text en Copyright: © 2016 Samivel et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Samivel, Ramachandran Kim, Dae Woo Son, Hye Ran Rhee, Yun-Hee Kim, Eun Hee Kim, Ji Hye Bae, Jun-Sang Chung, Young-Jun Chung, Phil-Sang Raz, Eyal Mo, Ji-Hun
spellingShingle	Samivel, Ramachandran Kim, Dae Woo Son, Hye Ran Rhee, Yun-Hee Kim, Eun Hee Kim, Ji Hye Bae, Jun-Sang Chung, Young-Jun Chung, Phil-Sang Raz, Eyal Mo, Ji-Hun The role of TRPV1 in the CD4+ T cell-mediated inflammatory response of allergic rhinitis
author_facet	Samivel, Ramachandran Kim, Dae Woo Son, Hye Ran Rhee, Yun-Hee Kim, Eun Hee Kim, Ji Hye Bae, Jun-Sang Chung, Young-Jun Chung, Phil-Sang Raz, Eyal Mo, Ji-Hun
author_sort	Samivel, Ramachandran
title	The role of TRPV1 in the CD4+ T cell-mediated inflammatory response of allergic rhinitis
title_short	The role of TRPV1 in the CD4+ T cell-mediated inflammatory response of allergic rhinitis
title_full	The role of TRPV1 in the CD4+ T cell-mediated inflammatory response of allergic rhinitis
title_fullStr	The role of TRPV1 in the CD4+ T cell-mediated inflammatory response of allergic rhinitis
title_full_unstemmed	The role of TRPV1 in the CD4+ T cell-mediated inflammatory response of allergic rhinitis
title_sort	role of trpv1 in the cd4+ t cell-mediated inflammatory response of allergic rhinitis
description	Transient receptor potential vanilloid 1 (TRPV1), which has been identified as a molecular target for the activation of sensory neurons by various painful stimuli, was reported to regulate the signaling and activation of CD4+ T cells. However, the role of TRPV1 in CD4+ T cell in allergic rhinitis remains poorly understood. In this study, TRPV1 expression was localized in CD4+ T cells. Both knockout and chemical inhibition of TRPV1 suppressed Th2/Th17 cytokine production in CD4 T cells and Jurkat T cells, respectively, and can suppress T cell receptor signaling pathways including NF-κB, MAP kinase, and NFAT. In TRPV1 knockout allergic rhinitis (AR) mice, eosinophil infiltration, Th2/Th17 cytokines in the nasal mucosa, and total and ova-specific IgE levels in serum decreased, compared with wild-type AR mice. The TRPV1 antagonists, BCTC or theobromine, showed similar inhibitory immunologic effects on AR mice models. In addition, the number of TRPV1+/CD4+ inflammatory cells increased in the nasal mucosa of patients with AR, compared with that of control subjects. Thus, TRPV1 activation on CD4+ T cells is involved in T cell receptor signaling, and it could be a novel therapeutic target in AR.
publisher	Impact Journals LLC
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807989/
_version_	1613557855161417728

The role of TRPV1 in the CD4+ T cell-mediated inflammatory response of allergic rhinitis

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