Cytogenetically Unrelated Clones in Acute Myeloid Leukemia Showing Different Responses to Chemotherapy

We report a case of acute myeloid leukemia (AML) with two cytogenetically unrelated clones. The patient was a 45-year-old male who was diagnosed with acute monoblastic leukemia (AMoL). Initial G-band analysis showed 51,XY,+6,+8,inv(9)(p12q13)c,+11,+13,+19[12]/52,idem,+Y[8], but G-band analysis after...

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Main Authors:	Kasahara, Kohei, Onozawa, Masahiro, Miyashita, Naohiro, Yokohata, Emi, Yoshida, Miho, Kanaya, Minoru, Kosugi-Kanaya, Mizuha, Takemura, Ryo, Takahashi, Shojiro, Sugita, Junichi, Shigematsu, Akio, Takahata, Mutsumi, Fujisawa, Shinichi, Hashimoto, Daigo, Fujimoto, Katsuya, Endo, Tomoyuki, Kondo, Takeshi, Teshima, Takanori
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806274/

id	pubmed-4806274
recordtype	oai_dc
spelling	pubmed-48062742016-03-31 Cytogenetically Unrelated Clones in Acute Myeloid Leukemia Showing Different Responses to Chemotherapy Kasahara, Kohei Onozawa, Masahiro Miyashita, Naohiro Yokohata, Emi Yoshida, Miho Kanaya, Minoru Kosugi-Kanaya, Mizuha Takemura, Ryo Takahashi, Shojiro Sugita, Junichi Shigematsu, Akio Takahata, Mutsumi Fujisawa, Shinichi Hashimoto, Daigo Fujimoto, Katsuya Endo, Tomoyuki Kondo, Takeshi Teshima, Takanori Case Report We report a case of acute myeloid leukemia (AML) with two cytogenetically unrelated clones. The patient was a 45-year-old male who was diagnosed with acute monoblastic leukemia (AMoL). Initial G-band analysis showed 51,XY,+6,+8,inv(9)(p12q13)c,+11,+13,+19[12]/52,idem,+Y[8], but G-band analysis after induction therapy showed 45,XY,-7,inv(9)(p12q13)c[19]/46,XY,inv(9)(p12q13)c[1]. Retrospective FISH analysis revealed a cryptic monosomy 7 clone in the initial AML sample. The clone with multiple trisomies was eliminated after induction therapy and never recurred, but a clone with monosomy 7 was still detected in myelodysplastic marrow with a normal blast percentage. Both clones were successfully eliminated after related peripheral blood stem cell transplantation, but the patient died of relapsed AML with monosomy 7. We concluded that one clone was de novo AMoL with chromosome 6, 8, 11, 13, and 19 trisomy and that the other was acute myeloid leukemia with myelodysplasia-related changes(AML-MRC) with chromosome 7 monosomy showing different responses to chemotherapy. Simultaneous onset of cytogenetically unrelated hematological malignancies that each have a different disease status is a rare phenomenon but is important to diagnose for a correct understanding of the disease status and for establishing an appropriate treatment strategy. Hindawi Publishing Corporation 2016 2016-03-10 /pmc/articles/PMC4806274/ /pubmed/27034857 http://dx.doi.org/10.1155/2016/2373902 Text en Copyright © 2016 Kohei Kasahara et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Kasahara, Kohei Onozawa, Masahiro Miyashita, Naohiro Yokohata, Emi Yoshida, Miho Kanaya, Minoru Kosugi-Kanaya, Mizuha Takemura, Ryo Takahashi, Shojiro Sugita, Junichi Shigematsu, Akio Takahata, Mutsumi Fujisawa, Shinichi Hashimoto, Daigo Fujimoto, Katsuya Endo, Tomoyuki Kondo, Takeshi Teshima, Takanori
spellingShingle	Kasahara, Kohei Onozawa, Masahiro Miyashita, Naohiro Yokohata, Emi Yoshida, Miho Kanaya, Minoru Kosugi-Kanaya, Mizuha Takemura, Ryo Takahashi, Shojiro Sugita, Junichi Shigematsu, Akio Takahata, Mutsumi Fujisawa, Shinichi Hashimoto, Daigo Fujimoto, Katsuya Endo, Tomoyuki Kondo, Takeshi Teshima, Takanori Cytogenetically Unrelated Clones in Acute Myeloid Leukemia Showing Different Responses to Chemotherapy
author_facet	Kasahara, Kohei Onozawa, Masahiro Miyashita, Naohiro Yokohata, Emi Yoshida, Miho Kanaya, Minoru Kosugi-Kanaya, Mizuha Takemura, Ryo Takahashi, Shojiro Sugita, Junichi Shigematsu, Akio Takahata, Mutsumi Fujisawa, Shinichi Hashimoto, Daigo Fujimoto, Katsuya Endo, Tomoyuki Kondo, Takeshi Teshima, Takanori
author_sort	Kasahara, Kohei
title	Cytogenetically Unrelated Clones in Acute Myeloid Leukemia Showing Different Responses to Chemotherapy
title_short	Cytogenetically Unrelated Clones in Acute Myeloid Leukemia Showing Different Responses to Chemotherapy
title_full	Cytogenetically Unrelated Clones in Acute Myeloid Leukemia Showing Different Responses to Chemotherapy
title_fullStr	Cytogenetically Unrelated Clones in Acute Myeloid Leukemia Showing Different Responses to Chemotherapy
title_full_unstemmed	Cytogenetically Unrelated Clones in Acute Myeloid Leukemia Showing Different Responses to Chemotherapy
title_sort	cytogenetically unrelated clones in acute myeloid leukemia showing different responses to chemotherapy
description	We report a case of acute myeloid leukemia (AML) with two cytogenetically unrelated clones. The patient was a 45-year-old male who was diagnosed with acute monoblastic leukemia (AMoL). Initial G-band analysis showed 51,XY,+6,+8,inv(9)(p12q13)c,+11,+13,+19[12]/52,idem,+Y[8], but G-band analysis after induction therapy showed 45,XY,-7,inv(9)(p12q13)c[19]/46,XY,inv(9)(p12q13)c[1]. Retrospective FISH analysis revealed a cryptic monosomy 7 clone in the initial AML sample. The clone with multiple trisomies was eliminated after induction therapy and never recurred, but a clone with monosomy 7 was still detected in myelodysplastic marrow with a normal blast percentage. Both clones were successfully eliminated after related peripheral blood stem cell transplantation, but the patient died of relapsed AML with monosomy 7. We concluded that one clone was de novo AMoL with chromosome 6, 8, 11, 13, and 19 trisomy and that the other was acute myeloid leukemia with myelodysplasia-related changes(AML-MRC) with chromosome 7 monosomy showing different responses to chemotherapy. Simultaneous onset of cytogenetically unrelated hematological malignancies that each have a different disease status is a rare phenomenon but is important to diagnose for a correct understanding of the disease status and for establishing an appropriate treatment strategy.
publisher	Hindawi Publishing Corporation
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806274/
_version_	1613557202352603136

Cytogenetically Unrelated Clones in Acute Myeloid Leukemia Showing Different Responses to Chemotherapy

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