The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin A

The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin A

Neuronal function is highly sensitive to changes in oxygen levels, but how hypoxia affects dendritic spine formation and synaptogenesis is unknown. Here we report that hypoxia, chemical inhibition of the oxygen-sensing prolyl hydroxylase domain proteins (PHDs), and silencing of Phd2 induce immature...

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Bibliographic Details
Main Authors: Segura, Inmaculada, Lange, Christian, Knevels, Ellen, Moskalyuk, Anastasiya, Pulizzi, Rocco, Eelen, Guy, Chaze, Thibault, Tudor, Cicerone, Boulegue, Cyril, Holt, Matthew, Daelemans, Dirk, Matondo, Mariette, Ghesquière, Bart, Giugliano, Michele, Ruiz de Almodovar, Carmen, Dewerchin, Mieke, Carmeliet, Peter
Format: Online
Language:English
Published: Cell Press 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805856/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805856/

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