Reduced Hyperpolarization-Activated Current Contributes to Enhanced Intrinsic Excitability in Cultured Hippocampal Neurons from PrP−/− Mice

Reduced Hyperpolarization-Activated Current Contributes to Enhanced Intrinsic Excitability in Cultured Hippocampal Neurons from PrP−/− Mice

Genetic ablation of cellular prion protein (PrPC) has been linked to increased neuronal excitability and synaptic activity in the hippocampus. We have previously shown that synaptic activity in hippocampi of PrP-null mice is increased due to enhanced N-methyl-D-aspartate receptor (NMDAR) function. H...

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Bibliographic Details
Main Authors: Fan, Jing, Stemkowski, Patrick L., Gandini, Maria A., Black, Stefanie A., Zhang, Zizhen, Souza, Ivana A., Chen, Lina, Zamponi, Gerald W.
Format: Online
Language:English
Published: Frontiers Media S.A. 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805597/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805597/

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