Tumor suppressive role of sestrin2 during colitis and colon carcinogenesis

Tumor suppressive role of sestrin2 during colitis and colon carcinogenesis

The mTOR complex 1 (mTORC1) and endoplasmic reticulum (ER) stress pathways are critical regulators of intestinal inflammation and colon cancer growth. Sestrins are stress-inducible proteins, which suppress both mTORC1 and ER stress; however, the role of Sestrins in colon physiology and tumorigenesis...

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Bibliographic Details
Main Authors: Ro, Seung-Hyun, Xue, Xiang, Ramakrishnan, Sadeesh K, Cho, Chun-Seok, Namkoong, Sim, Jang, Insook, Semple, Ian A, Ho, Allison, Park, Hwan-Woo, Shah, Yatrik M, Lee, Jun Hee
Format: Online
Language:English
Published: eLife Sciences Publications, Ltd 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805551/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805551/

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