Internal genomic regions mobilized for telomere maintenance in C. elegans

Because DNA polymerase cannot replicate telomeric DNA at linear chromosomal ends, eukaryotes have developed specific telomere maintenance mechanisms (TMMs). A major TMM involves specialized reverse transcriptase, telomerase. However, there also exist various telomerase-independent TMMs (TI-TMMs), wh...

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Main Authors:	Kim, Chuna, Sung, Sanghyun, Lee, Junho
Format:	Online
Language:	English
Published:	Taylor & Francis 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805358/

id	pubmed-4805358
recordtype	oai_dc
spelling	pubmed-48053582016-04-12 Internal genomic regions mobilized for telomere maintenance in C. elegans Kim, Chuna Sung, Sanghyun Lee, Junho Commentary Because DNA polymerase cannot replicate telomeric DNA at linear chromosomal ends, eukaryotes have developed specific telomere maintenance mechanisms (TMMs). A major TMM involves specialized reverse transcriptase, telomerase. However, there also exist various telomerase-independent TMMs (TI-TMMs), which can arise both in pathological conditions (such as cancers) and during evolution. The TI-TMM in cancer cells is called alternative lengthening of telomeres (ALT), whose mechanism is not fully understood. We generated stably maintained telomerase-independent survivors from C. elegans telomerase mutants and found that, unlike previously described survivors in worms, these survivors “mobilize” specific internal sequence blocks for telomere lengthening, which we named TALTs (templates for ALT). The cis-duplication of internal genomic TALTs produces “reservoirs” of TALTs, whose trans-duplication occurs at all chromosome ends in the ALT survivors. Our discovery that different TALTs are utilized in different wild isolates provides insight into the molecular events leading to telomere evolution. Taylor & Francis 2016-03-08 /pmc/articles/PMC4805358/ /pubmed/27073737 http://dx.doi.org/10.1080/21624054.2016.1146856 Text en © 2016 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0/, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Kim, Chuna Sung, Sanghyun Lee, Junho
spellingShingle	Kim, Chuna Sung, Sanghyun Lee, Junho Internal genomic regions mobilized for telomere maintenance in C. elegans
author_facet	Kim, Chuna Sung, Sanghyun Lee, Junho
author_sort	Kim, Chuna
title	Internal genomic regions mobilized for telomere maintenance in C. elegans
title_short	Internal genomic regions mobilized for telomere maintenance in C. elegans
title_full	Internal genomic regions mobilized for telomere maintenance in C. elegans
title_fullStr	Internal genomic regions mobilized for telomere maintenance in C. elegans
title_full_unstemmed	Internal genomic regions mobilized for telomere maintenance in C. elegans
title_sort	internal genomic regions mobilized for telomere maintenance in c. elegans
description	Because DNA polymerase cannot replicate telomeric DNA at linear chromosomal ends, eukaryotes have developed specific telomere maintenance mechanisms (TMMs). A major TMM involves specialized reverse transcriptase, telomerase. However, there also exist various telomerase-independent TMMs (TI-TMMs), which can arise both in pathological conditions (such as cancers) and during evolution. The TI-TMM in cancer cells is called alternative lengthening of telomeres (ALT), whose mechanism is not fully understood. We generated stably maintained telomerase-independent survivors from C. elegans telomerase mutants and found that, unlike previously described survivors in worms, these survivors “mobilize” specific internal sequence blocks for telomere lengthening, which we named TALTs (templates for ALT). The cis-duplication of internal genomic TALTs produces “reservoirs” of TALTs, whose trans-duplication occurs at all chromosome ends in the ALT survivors. Our discovery that different TALTs are utilized in different wild isolates provides insight into the molecular events leading to telomere evolution.
publisher	Taylor & Francis
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805358/
_version_	1613557031810105344

Internal genomic regions mobilized for telomere maintenance in C. elegans

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