Tuberculous Panophthalmitis with Lymphadenitis and Central Nervous System Tuberculoma

Tuberculosis (TB) is a serious infectious disease that spreads globally. The ocular manifestations of TB are uncommon and diverse. TB panophthalmitis has been rarely reported. Here, we described a 38-year-old Thai man presenting with panophthalmitis of the right eye. Further investigation showed tha...

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Main Authors:	Srichatrapimuk, Sirawat, Wattanatranon, Duangkamon, Sungkanuparph, Somnuek
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4804051/

id	pubmed-4804051
recordtype	oai_dc
spelling	pubmed-48040512016-04-05 Tuberculous Panophthalmitis with Lymphadenitis and Central Nervous System Tuberculoma Srichatrapimuk, Sirawat Wattanatranon, Duangkamon Sungkanuparph, Somnuek Case Report Tuberculosis (TB) is a serious infectious disease that spreads globally. The ocular manifestations of TB are uncommon and diverse. TB panophthalmitis has been rarely reported. Here, we described a 38-year-old Thai man presenting with panophthalmitis of the right eye. Further investigation showed that he had concurrent TB lymphadenitis and central nervous system (CNS) tuberculoma, as well as HIV infection, with a CD4 cell count of 153 cells/mm3. Despite the initial response to antituberculous agents, the disease had subsequently progressed and enucleation was required. The pathological examination revealed acute suppurative granulomatous panophthalmitis with retinal detachment. Further staining demonstrated acid-fast bacilli in the tissue. Colonies of Mycobacterium tuberculosis were obtained from tissue culture. He was treated with antiretroviral agents for HIV infection and 12 months of antituberculous agents. Clinicians should be aware of the possibility of TB in the differential diagnosis of endophthalmitis and panophthalmitis, especially in regions where TB is endemic. Hindawi Publishing Corporation 2016 2016-03-09 /pmc/articles/PMC4804051/ /pubmed/27051539 http://dx.doi.org/10.1155/2016/6785382 Text en Copyright © 2016 Sirawat Srichatrapimuk et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Srichatrapimuk, Sirawat Wattanatranon, Duangkamon Sungkanuparph, Somnuek
spellingShingle	Srichatrapimuk, Sirawat Wattanatranon, Duangkamon Sungkanuparph, Somnuek Tuberculous Panophthalmitis with Lymphadenitis and Central Nervous System Tuberculoma
author_facet	Srichatrapimuk, Sirawat Wattanatranon, Duangkamon Sungkanuparph, Somnuek
author_sort	Srichatrapimuk, Sirawat
title	Tuberculous Panophthalmitis with Lymphadenitis and Central Nervous System Tuberculoma
title_short	Tuberculous Panophthalmitis with Lymphadenitis and Central Nervous System Tuberculoma
title_full	Tuberculous Panophthalmitis with Lymphadenitis and Central Nervous System Tuberculoma
title_fullStr	Tuberculous Panophthalmitis with Lymphadenitis and Central Nervous System Tuberculoma
title_full_unstemmed	Tuberculous Panophthalmitis with Lymphadenitis and Central Nervous System Tuberculoma
title_sort	tuberculous panophthalmitis with lymphadenitis and central nervous system tuberculoma
description	Tuberculosis (TB) is a serious infectious disease that spreads globally. The ocular manifestations of TB are uncommon and diverse. TB panophthalmitis has been rarely reported. Here, we described a 38-year-old Thai man presenting with panophthalmitis of the right eye. Further investigation showed that he had concurrent TB lymphadenitis and central nervous system (CNS) tuberculoma, as well as HIV infection, with a CD4 cell count of 153 cells/mm3. Despite the initial response to antituberculous agents, the disease had subsequently progressed and enucleation was required. The pathological examination revealed acute suppurative granulomatous panophthalmitis with retinal detachment. Further staining demonstrated acid-fast bacilli in the tissue. Colonies of Mycobacterium tuberculosis were obtained from tissue culture. He was treated with antiretroviral agents for HIV infection and 12 months of antituberculous agents. Clinicians should be aware of the possibility of TB in the differential diagnosis of endophthalmitis and panophthalmitis, especially in regions where TB is endemic.
publisher	Hindawi Publishing Corporation
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4804051/
_version_	1613556544241139712

Tuberculous Panophthalmitis with Lymphadenitis and Central Nervous System Tuberculoma

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