K-Ras protein as a drug target
K-Ras proteins are major drivers of human cancers, playing a direct causal role in about one million cancer cases/year. In cancers driven by mutant K-Ras, the protein is locked in the active, GTP-bound state constitutively, through a defect in the off-switch mechanism. As such, the mutant protein re...
| Main Author: | |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
Springer Berlin Heidelberg
2016
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4803814/ |