Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation
Histone methylation regulates DNA repair. However, the mechanisms that underlie the regulation of histone methylation during this repair remain to be further defined. Here, we show that ionizing radiation (IR) induces DNA-PK-dependent phosphorylation of nuclear fumarase at T236, which leads to an in...
| Main Authors: | , , , , , , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4800990/ |