Deletion of Galectin-3 Enhances Xenobiotic Induced Murine Primary Biliary Cholangitis by Facilitating Apoptosis of BECs and Release of Autoantigens

Deletion of Galectin-3 Enhances Xenobiotic Induced Murine Primary Biliary Cholangitis by Facilitating Apoptosis of BECs and Release of Autoantigens

Galectin-3 (Gal-3) is a carbohydrate binding lectin, with multiple roles in inflammatory diseases and autoimmunity including its antiapoptotic effect on epithelial cells. In particular, increased expression of Gal-3 in epithelial cells is protective from apoptosis. Based on the thesis that apoptosis...

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Bibliographic Details
Main Authors: Arsenijevic, Aleksandar, Milovanovic, Marija, Milovanovic, Jelena, Stojanovic, Bojana, Zdravkovic, Natasa, Leung, Patrick S.C., Liu, Fu-Tong, Gershwin, M. Eric, Lukic, Miodrag L.
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4800400/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4800400/

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