Hypercapnia modulates cAMP signalling and cystic fibrosis transmembrane conductance regulator‐dependent anion and fluid secretion in airway epithelia

Hypercapnia modulates cAMP signalling and cystic fibrosis transmembrane conductance regulator‐dependent anion and fluid secretion in airway epithelia

Raised arterial blood CO2 (hypercapnia) is a feature of many lung diseases.CO2 has been shown to act as a cell signalling molecule in human cells, notably by influencing the levels of cell signalling second messengers: cAMP and Ca2+.Hypercapnia reduced cAMP‐stimulated cystic fibrosis transmembrane...

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Bibliographic Details
Main Authors: Turner, Mark J., Saint‐Criq, Vinciane, Patel, Waseema, Ibrahim, Salam H., Verdon, Bernard, Ward, Christopher, Garnett, James P., Tarran, Robert, Cann, Martin J., Gray, Michael A.
Format: Online
Language:English
Published: John Wiley and Sons Inc. 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4799982/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4799982/

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