Aurora-A mediated histone H3 phosphorylation of threonine 118 controls condensin I and cohesin occupancy in mitosis

Aurora-A mediated histone H3 phosphorylation of threonine 118 controls condensin I and cohesin occupancy in mitosis

Phosphorylation of histone H3 threonine 118 (H3 T118ph) weakens histone DNA-contacts, disrupting the nucleosome structure. We show that Aurora-A mediated H3 T118ph occurs at pericentromeres and chromosome arms during prophase and is lost upon chromosome alignment. Expression of H3 T118E or H3 T118I...

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Bibliographic Details
Main Authors: Wike, Candice L, Graves, Hillary K, Hawkins, Reva, Gibson, Matthew D, Ferdinand, Michelle B, Zhang, Tao, Chen, Zhihong, Hudson, Damien F, Ottesen, Jennifer J, Poirier, Michael G, Schumacher, Jill, Tyler, Jessica K
Format: Online
Language:English
Published: eLife Sciences Publications, Ltd 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4798946/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4798946/

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