Sample size calculations in clinical research should also be based on ethical principles

Sample size calculations based on too narrow a width, or with lower and upper confidence limits bounded by fixed cut-off points, not only increase power-based sample sizes to ethically unacceptable levels (thus making research practically unfeasible) but also greatly increase the costs and burdens o...

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Bibliographic Details
Main Authors: Cesana, Bruno Mario, Antonelli, Paolo
Format: Online
Language:English
Published: BioMed Central 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4797226/