Clec16a is Critical for Autolysosome Function and Purkinje Cell Survival

Clec16a is Critical for Autolysosome Function and Purkinje Cell Survival

CLEC16A is in a locus genetically linked to autoimmune diseases including multiple sclerosis, but the function of this gene in the nervous system is unknown. Here we show that two mouse strains carrying independent Clec16a mutations developed neurodegenerative disease characterized by motor impairme...

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Bibliographic Details
Main Authors: Redmann, Veronika, Lamb, Christopher A., Hwang, Seungmin, Orchard, Robert C., Kim, Sungsu, Razi, Minoo, Milam, Ashley, Park, Sunmin, Yokoyama, Christine C., Kambal, Amal, Kreamalmeyer, Darren, Bosch, Marie K., Xiao, Maolei, Green, Karen, Kim, Jungsu, Pruett-Miller, Shondra M., Ornitz, David M., Allen, Paul M., Beatty, Wandy L., Schmidt, Robert E., DiAntonio, Aaron, Tooze, Sharon A., Virgin, Herbert W.
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4796910/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4796910/

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