Breast cancer survival among young women: a review of the role of modifiable lifestyle factors
Almost 7 % of breast cancers are diagnosed among women age 40 years and younger in Western populations. Clinical outcomes among young women are worse. Early age-of-onset increases the risk of contralateral breast cancer, local and distant recurrence, and subsequent mortality. Breast cancers in youn...
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Springer International Publishing
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4796361/ |
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pubmed-47963612016-04-10 Breast cancer survival among young women: a review of the role of modifiable lifestyle factors Brenner, Darren R. Brockton, Nigel T. Kotsopoulos, Joanne Cotterchio, Michelle Boucher, Beatrice A. Courneya, Kerry S. Knight, Julia A. Olivotto, Ivo A. Quan, May Lynn Friedenreich, Christine M. Review Article Almost 7 % of breast cancers are diagnosed among women age 40 years and younger in Western populations. Clinical outcomes among young women are worse. Early age-of-onset increases the risk of contralateral breast cancer, local and distant recurrence, and subsequent mortality. Breast cancers in young women (BCYW) are more likely to present with triple-negative (TNBC), TP53-positive, and HER-2 over-expressing tumors than among older women. However, despite these known differences in breast cancer outcomes and tumor subtypes, there is limited understanding of the basic biology, epidemiology, and optimal therapeutic strategies for BCYW. Several modifiable lifestyle factors associated with reduced risk of developing breast cancer have also been implicated in improved prognosis among breast cancer survivors of all ages. Given the treatment-related toxicities and the extended window for late effects, long-term lifestyle modifications potentially offer significant benefits to BCYW. In this review, we propose a model identifying three main areas of lifestyle factors (energy imbalance, inflammation, and dietary nutrient adequacy) that may influence survival in BCYW. In addition, we provide a summary of mechanisms of action and a synthesis of previous research on each of these topics. Springer International Publishing 2016-03-12 2016 /pmc/articles/PMC4796361/ /pubmed/26970739 http://dx.doi.org/10.1007/s10552-016-0726-5 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Brenner, Darren R. Brockton, Nigel T. Kotsopoulos, Joanne Cotterchio, Michelle Boucher, Beatrice A. Courneya, Kerry S. Knight, Julia A. Olivotto, Ivo A. Quan, May Lynn Friedenreich, Christine M. |
| spellingShingle |
Brenner, Darren R. Brockton, Nigel T. Kotsopoulos, Joanne Cotterchio, Michelle Boucher, Beatrice A. Courneya, Kerry S. Knight, Julia A. Olivotto, Ivo A. Quan, May Lynn Friedenreich, Christine M. Breast cancer survival among young women: a review of the role of modifiable lifestyle factors |
| author_facet |
Brenner, Darren R. Brockton, Nigel T. Kotsopoulos, Joanne Cotterchio, Michelle Boucher, Beatrice A. Courneya, Kerry S. Knight, Julia A. Olivotto, Ivo A. Quan, May Lynn Friedenreich, Christine M. |
| author_sort |
Brenner, Darren R. |
| title |
Breast cancer survival among young women: a review of the role of modifiable lifestyle factors |
| title_short |
Breast cancer survival among young women: a review of the role of modifiable lifestyle factors |
| title_full |
Breast cancer survival among young women: a review of the role of modifiable lifestyle factors |
| title_fullStr |
Breast cancer survival among young women: a review of the role of modifiable lifestyle factors |
| title_full_unstemmed |
Breast cancer survival among young women: a review of the role of modifiable lifestyle factors |
| title_sort |
breast cancer survival among young women: a review of the role of modifiable lifestyle factors |
| description |
Almost 7 % of breast cancers are diagnosed among women age 40 years and younger in Western populations. Clinical outcomes among young women are worse. Early age-of-onset increases the risk of contralateral breast cancer, local and distant recurrence, and subsequent mortality. Breast cancers in young women (BCYW) are more likely to present with triple-negative (TNBC), TP53-positive, and HER-2 over-expressing tumors than among older women. However, despite these known differences in breast cancer outcomes and tumor subtypes, there is limited understanding of the basic biology, epidemiology, and optimal therapeutic strategies for BCYW. Several modifiable lifestyle factors associated with reduced risk of developing breast cancer have also been implicated in improved prognosis among breast cancer survivors of all ages. Given the treatment-related toxicities and the extended window for late effects, long-term lifestyle modifications potentially offer significant benefits to BCYW. In this review, we propose a model identifying three main areas of lifestyle factors (energy imbalance, inflammation, and dietary nutrient adequacy) that may influence survival in BCYW. In addition, we provide a summary of mechanisms of action and a synthesis of previous research on each of these topics. |
| publisher |
Springer International Publishing |
| publishDate |
2016 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4796361/ |
| _version_ |
1613553411628728320 |