Associations of functional alanine-glyoxylate aminotransferase 2 gene variants with atrial fibrillation and ischemic stroke

Associations of functional alanine-glyoxylate aminotransferase 2 gene variants with atrial fibrillation and ischemic stroke

Asymmetric and symmetric dimethylarginines (ADMA and SDMA) impair nitric oxide bioavailability and have been implicated in the pathogenesis of atrial fibrillation (AF). Alanine–glyoxylate aminotransferase 2 (AGXT2) is the only enzyme capable of metabolizing both of the dimethylarginines. We hypothes...

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Main Authors: Seppälä, Ilkka, Kleber, Marcus E., Bevan, Steve, Lyytikäinen, Leo-Pekka, Oksala, Niku, Hernesniemi, Jussi A., Mäkelä, Kari-Matti, Rothwell, Peter M., Sudlow, Cathie, Dichgans, Martin, Mononen, Nina, Vlachopoulou, Efthymia, Sinisalo, Juha, Delgado, Graciela E., Laaksonen, Reijo, Koskinen, Tuomas, Scharnagl, Hubert, Kähönen, Mika, Markus, Hugh S., März, Winfried, Lehtimäki, Terho
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794714/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794714/

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