Externalized decondensed neutrophil chromatin occludes pancreatic ducts and drives pancreatitis

Externalized decondensed neutrophil chromatin occludes pancreatic ducts and drives pancreatitis

Ductal occlusion has been postulated to precipitate focal pancreatic inflammation, while the nature of the primary occluding agents has remained elusive. Neutrophils make use of histone citrullination by peptidyl arginine deiminase-4 (PADI4) in contact to particulate agents to extrude decondensed ch...

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Bibliographic Details
Main Authors: Leppkes, Moritz, Maueröder, Christian, Hirth, Sebastian, Nowecki, Stefanie, Günther, Claudia, Billmeier, Ulrike, Paulus, Susanne, Biermann, Mona, Munoz, Luis E., Hoffmann, Markus, Wildner, Dane, Croxford, Andrew L., Waisman, Ari, Mowen, Kerri, Jenne, Dieter E., Krenn, Veit, Mayerle, Julia, Lerch, Markus M., Schett, Georg, Wirtz, Stefan, Neurath, Markus F., Herrmann, Martin, Becker, Christoph
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4793047/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4793047/

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