The RyR2-P2328S mutation downregulates Nav1.5 producing arrhythmic substrate in murine ventricles

The RyR2-P2328S mutation downregulates Nav1.5 producing arrhythmic substrate in murine ventricles

Catecholaminergic polymorphic ventricular tachycardia (CPVT) predisposes to ventricular arrhythmia due to altered Ca2+ homeostasis and can arise from ryanodine receptor (RyR2) mutations including RyR2-P2328S. Previous reports established that homozygotic murine RyR2-P2328S (RyR2S/S) hearts show an a...

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Bibliographic Details
Main Authors: Ning, Feifei, Luo, Ling, Ahmad, Shiraz, Valli, Haseeb, Jeevaratnam, Kamalan, Wang, Tingzhong, Guzadhur, Laila, Yang, Dandan, Fraser, James A., Huang, Christopher L.-H., Ma, Aiqun, Salvage, Samantha C.
Format: Online
Language:English
Published: Springer Berlin Heidelberg 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792352/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792352/

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