LncRNA HOTAIR enhances ER signaling and confers tamoxifen resistance in breast cancer

Tamoxifen, an estrogen receptor (ER) antagonist, is the mainstay treatment of breast cancer and the development of resistance represents a major obstacle for a cure. Although lncRNAs such as HOTAIR have been implicated in breast tumorigenesis, their roles in chemotherapy resistance remain largely un...

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Bibliographic Details
Main Authors: Xue, Xingyang, Yang, Yeqing Angela, Zhang, Ali, Fong, Ka-wing, Kim, Jung, Song, Bing, Li, Shangze, Zhao, Jonathan C., Yu, Jindan
Format: Online
Language:English
Published: 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791209/