Structure and mechanism of activity-based inhibition of the EGF-Receptor by Mig6

Structure and mechanism of activity-based inhibition of the EGF-Receptor by Mig6

Mig6 is a feedback inhibitor that directly binds, inhibits and drives internalization of ErbB-family receptors. Mig6 selectivity targets activated receptors. Here we find that the EGF receptor phosphorylates Mig6 on Tyr394, and that this phosphorylation is primed by prior phosphorylation of an adjac...

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Bibliographic Details
Main Authors: Park, Eunyoung, Kim, Nayoung, Ficarro, Scott B., Zhang, Yi, Lee, Byung Il, Cho, Ahye, Kim, Kihong, Park, Angela K.J., Park, Woong-Yang, Murray, Bradley, Meyerson, Matthew, Beroukhim, Rameen, Marto, Jarrod A., Cho, Jeonghee, Eck, Michael J.
Format: Online
Language:English
Published: 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4790445/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4790445/

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