Clinical relevance of the discrepancy in phenylalanine concentrations analyzed using tandem mass spectrometry compared with ion-exchange chromatography in phenylketonuria

Clinical relevance of the discrepancy in phenylalanine concentrations analyzed using tandem mass spectrometry compared with ion-exchange chromatography in phenylketonuria

•Phe concentration in dried blood spots is significantly lower than plasma phe.•Blood phe concentration cannot be adjusted due to large variability across subjects.•Analysis of dried blood spots using IEC instead of MS/MS improves accuracy.•Plasma phe concentration using IEC is the most accurate for...

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Bibliographic Details
Main Authors: Stroup, Bridget M., Held, Patrice K., Williams, Phillip, Clayton, Murray K., Murali, Sangita G., Rice, Gregory M., Ney, Denise M.
Format: Online
Language:English
Published: Elsevier 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789345/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789345/

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