Dysregulation of microRNA biogenesis in cancer: the impact of mutant p53 on Drosha complex activity
A widespread decrease of mature microRNAs is often observed in human malignancies giving them potential to act as tumor suppressors. Thus, microRNAs may be potential targets for cancer therapy. The global miRNA deregulation is often the result of defects in the miRNA biogenesis pathway, such as geno...
| Main Authors: | , , , |
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| Format: | Online |
| Language: | English |
| Published: |
BioMed Central
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789259/ |