The ubiquitin ligase HERC3 attenuates NF-κB-dependent transcription independently of its enzymatic activity by delivering the RelA subunit for degradation

The ubiquitin ligase HERC3 attenuates NF-κB-dependent transcription independently of its enzymatic activity by delivering the RelA subunit for degradation

Activation of NF-κB-dependent transcription represents an important hallmark of inflammation. While the acute inflammatory response is per se beneficial, it can become deleterious if its spatial and temporal profile is not tightly controlled. Classically, NF-κB activity is limited by cytoplasmic ret...

Full description

Bibliographic Details
Main Authors: Hochrainer, Karin, Pejanovic, Nadja, Olaseun, Victoria A., Zhang, Sheng, Iadecola, Costantino, Anrather, Josef
Format: Online
Language:English
Published: Oxford University Press 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4787756/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4787756/

Similar Items