Trivalent Gd-DOTA reagents for modification of proteins† †Electronic supplementary information (ESI) available: Synthetic details for known compounds; materials and methods for bioconjugation reactions; copies of spectra of new compounds and compounds prepared according to new procedures. See DOI: 10.1039/c5ra20359g Click here for additional data file.

Trivalent Gd-DOTA reagents for modification of proteins† †Electronic supplementary information (ESI) available: Synthetic details for known compounds; materials and methods for bioconjugation reactions; copies of spectra of new compounds and compounds prepared according to new procedures. See DOI: 10.1039/c5ra20359g Click here for additional data file.

The development of novel protein-targeted MRI contrast agents crucially depends on the ability to derivatise suitable targeting moieties with a high payload of relaxation enhancer without losing affinity for the target proteins.

Bibliographic Details
Main Authors: Fisher, Martin J., Williamson, Daniel J., Burslem, George M., Plante, Jeffrey P., Manfield, Iain W., Tiede, Christian, Ault, James R., Stockley, Peter G., Plein, Sven, Maqbool, Azhar, Tomlinson, Darren C., Foster, Richard, Warriner, Stuart L., Bon, Robin S.
Format: Online
Language:English
Published: Royal Society of Chemistry 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786947/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786947/

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