Increased amyloidogenic APP processing in APOE ɛ4-negative individuals with cerebral β-amyloidosis

Increased amyloidogenic APP processing in APOE ɛ4-negative individuals with cerebral β-amyloidosis

Increased APP (amyloid precursor protein) processing causes β-amyloid (Aβ) accumulation in autosomal dominant Alzheimer's disease (AD), but it is unclear if it also affects sporadic Aβ accumulation. We tested healthy controls and patients with mild cognitive symptoms (N=331) in the BioFINDER st...

Full description

Bibliographic Details
Main Authors: Mattsson, Niklas, Insel, Philip S., Palmqvist, Sebastian, Stomrud, Erik, van Westen, Danielle, Minthon, Lennart, Zetterberg, Henrik, Blennow, Kaj, Hansson, Oskar
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786682/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786682/

Similar Items