Relationship between Erythrocyte Fatty Acid Composition and Psychopathology in the Vienna Omega-3 Study

This study investigated the relationship between erythrocyte membrane fatty acid (FA) levels and the severity of symptoms of individuals at ultra-high risk (UHR) for psychosis. Subjects of the present study consisted of 80 neuroleptic-naïve UHR patients. Partial correlation coefficients were calcula...

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Main Authors:	Kim, Sung-Wan, Jhon, Min, Kim, Jae-Min, Smesny, Stefan, Rice, Simon, Berk, Michael, Klier, Claudia M., McGorry, Patrick D., Schäfer, Miriam R., Amminger, G. Paul
Format:	Online
Language:	English
Published:	Public Library of Science 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786267/

id	pubmed-4786267
recordtype	oai_dc
spelling	pubmed-47862672016-03-23 Relationship between Erythrocyte Fatty Acid Composition and Psychopathology in the Vienna Omega-3 Study Kim, Sung-Wan Jhon, Min Kim, Jae-Min Smesny, Stefan Rice, Simon Berk, Michael Klier, Claudia M. McGorry, Patrick D. Schäfer, Miriam R. Amminger, G. Paul Research Article This study investigated the relationship between erythrocyte membrane fatty acid (FA) levels and the severity of symptoms of individuals at ultra-high risk (UHR) for psychosis. Subjects of the present study consisted of 80 neuroleptic-naïve UHR patients. Partial correlation coefficients were calculated between baseline erythrocyte membrane FA levels, measured by gas chromatography, and scores on the Positive and Negative Syndrome Scale (PANSS), Global Assessment of Functioning Scale, and Montgomery–Asberg Depression Rating Scale (MADRS) after controlling for age, sex, smoking and cannabis use. Subjects were divided into three groups according to the predominance of positive or negative symptoms based on PANSS subscale scores; membrane FA levels in the three groups were then compared. More severe negative symptoms measured by PANSS were negatively correlated with two saturated FAs (myristic and margaric acids), one ω-9 monounsaturated FA (MUFA; nervonic acid), and one ω-3 polyunsaturated FA (PUFA; docosapentaenoic acid), and were positively correlated with two ω-9 MUFAs (eicosenoic and erucic acids) and two ω-6 PUFAs (γ-linolenic and docosadienoic acids). More severe positive symptoms measured by PANSS were correlated only with nervonic acid. No associations were observed between FAs and MADRS scores. In subjects with predominant negative symptoms, the sum of the ω-9 MUFAs and the ω-6:ω-3 FA ratio were both significantly higher than in those with predominant positive symptoms, whereas the sum of ω-3 PUFAs was significantly lower. In conclusion, abnormalities in FA metabolism may contribute to the neurobiology of psychopathology in UHR individuals. In particular, membrane FA alterations may play a role in negative symptoms, which are primary psychopathological manifestations of schizophrenia-related disability. Public Library of Science 2016-03-10 /pmc/articles/PMC4786267/ /pubmed/26963912 http://dx.doi.org/10.1371/journal.pone.0151417 Text en © 2016 Kim et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Kim, Sung-Wan Jhon, Min Kim, Jae-Min Smesny, Stefan Rice, Simon Berk, Michael Klier, Claudia M. McGorry, Patrick D. Schäfer, Miriam R. Amminger, G. Paul
spellingShingle	Kim, Sung-Wan Jhon, Min Kim, Jae-Min Smesny, Stefan Rice, Simon Berk, Michael Klier, Claudia M. McGorry, Patrick D. Schäfer, Miriam R. Amminger, G. Paul Relationship between Erythrocyte Fatty Acid Composition and Psychopathology in the Vienna Omega-3 Study
author_facet	Kim, Sung-Wan Jhon, Min Kim, Jae-Min Smesny, Stefan Rice, Simon Berk, Michael Klier, Claudia M. McGorry, Patrick D. Schäfer, Miriam R. Amminger, G. Paul
author_sort	Kim, Sung-Wan
title	Relationship between Erythrocyte Fatty Acid Composition and Psychopathology in the Vienna Omega-3 Study
title_short	Relationship between Erythrocyte Fatty Acid Composition and Psychopathology in the Vienna Omega-3 Study
title_full	Relationship between Erythrocyte Fatty Acid Composition and Psychopathology in the Vienna Omega-3 Study
title_fullStr	Relationship between Erythrocyte Fatty Acid Composition and Psychopathology in the Vienna Omega-3 Study
title_full_unstemmed	Relationship between Erythrocyte Fatty Acid Composition and Psychopathology in the Vienna Omega-3 Study
title_sort	relationship between erythrocyte fatty acid composition and psychopathology in the vienna omega-3 study
description	This study investigated the relationship between erythrocyte membrane fatty acid (FA) levels and the severity of symptoms of individuals at ultra-high risk (UHR) for psychosis. Subjects of the present study consisted of 80 neuroleptic-naïve UHR patients. Partial correlation coefficients were calculated between baseline erythrocyte membrane FA levels, measured by gas chromatography, and scores on the Positive and Negative Syndrome Scale (PANSS), Global Assessment of Functioning Scale, and Montgomery–Asberg Depression Rating Scale (MADRS) after controlling for age, sex, smoking and cannabis use. Subjects were divided into three groups according to the predominance of positive or negative symptoms based on PANSS subscale scores; membrane FA levels in the three groups were then compared. More severe negative symptoms measured by PANSS were negatively correlated with two saturated FAs (myristic and margaric acids), one ω-9 monounsaturated FA (MUFA; nervonic acid), and one ω-3 polyunsaturated FA (PUFA; docosapentaenoic acid), and were positively correlated with two ω-9 MUFAs (eicosenoic and erucic acids) and two ω-6 PUFAs (γ-linolenic and docosadienoic acids). More severe positive symptoms measured by PANSS were correlated only with nervonic acid. No associations were observed between FAs and MADRS scores. In subjects with predominant negative symptoms, the sum of the ω-9 MUFAs and the ω-6:ω-3 FA ratio were both significantly higher than in those with predominant positive symptoms, whereas the sum of ω-3 PUFAs was significantly lower. In conclusion, abnormalities in FA metabolism may contribute to the neurobiology of psychopathology in UHR individuals. In particular, membrane FA alterations may play a role in negative symptoms, which are primary psychopathological manifestations of schizophrenia-related disability.
publisher	Public Library of Science
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786267/
_version_	1613550211266772992

Relationship between Erythrocyte Fatty Acid Composition and Psychopathology in the Vienna Omega-3 Study

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