Key enzymes catalyzing glycerol to 1,3-propanediol
Biodiesel can replace petroleum diesel as it is produced from animal fats and vegetable oils, and it produces about 10 % (w/w) glycerol, which is a promising new industrial microbial carbon, as a major by-product. One of the most potential applications of glycerol is its biotransformation to high va...
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BioMed Central
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785665/ |
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pubmed-47856652016-03-11 Key enzymes catalyzing glycerol to 1,3-propanediol Jiang, Wei Wang, Shizhen Wang, Yuanpeng Fang, Baishan Review Biodiesel can replace petroleum diesel as it is produced from animal fats and vegetable oils, and it produces about 10 % (w/w) glycerol, which is a promising new industrial microbial carbon, as a major by-product. One of the most potential applications of glycerol is its biotransformation to high value chemicals such as 1,3-propanediol (1,3-PD), dihydroxyacetone (DHA), succinic acid, etc., through microbial fermentation. Glycerol dehydratase, 1,3-propanediol dehydrogenase (1,3-propanediol-oxydoreductase), and glycerol dehydrogenase, which were encoded, respectively, by dhaB, dhaT, and dhaD and with DHA kinase are encompassed by the dha regulon, are the three key enzymes in glycerol bioconversion into 1,3-PD and DHA, and these are discussed in this review article. The summary of the main research direction of these three key enzyme and methods of glycerol bioconversion into 1,3-PD and DHA indicates their potential application in future enzymatic research and industrial production, especially in biodiesel industry. BioMed Central 2016-03-10 /pmc/articles/PMC4785665/ /pubmed/26966462 http://dx.doi.org/10.1186/s13068-016-0473-6 Text en © Jiang et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Jiang, Wei Wang, Shizhen Wang, Yuanpeng Fang, Baishan |
| spellingShingle |
Jiang, Wei Wang, Shizhen Wang, Yuanpeng Fang, Baishan Key enzymes catalyzing glycerol to 1,3-propanediol |
| author_facet |
Jiang, Wei Wang, Shizhen Wang, Yuanpeng Fang, Baishan |
| author_sort |
Jiang, Wei |
| title |
Key enzymes catalyzing glycerol to 1,3-propanediol |
| title_short |
Key enzymes catalyzing glycerol to 1,3-propanediol |
| title_full |
Key enzymes catalyzing glycerol to 1,3-propanediol |
| title_fullStr |
Key enzymes catalyzing glycerol to 1,3-propanediol |
| title_full_unstemmed |
Key enzymes catalyzing glycerol to 1,3-propanediol |
| title_sort |
key enzymes catalyzing glycerol to 1,3-propanediol |
| description |
Biodiesel can replace petroleum diesel as it is produced from animal fats and vegetable oils, and it produces about 10 % (w/w) glycerol, which is a promising new industrial microbial carbon, as a major by-product. One of the most potential applications of glycerol is its biotransformation to high value chemicals such as 1,3-propanediol (1,3-PD), dihydroxyacetone (DHA), succinic acid, etc., through microbial fermentation. Glycerol dehydratase, 1,3-propanediol dehydrogenase (1,3-propanediol-oxydoreductase), and glycerol dehydrogenase, which were encoded, respectively, by dhaB, dhaT, and dhaD and with DHA kinase are encompassed by the dha regulon, are the three key enzymes in glycerol bioconversion into 1,3-PD and DHA, and these are discussed in this review article. The summary of the main research direction of these three key enzyme and methods of glycerol bioconversion into 1,3-PD and DHA indicates their potential application in future enzymatic research and industrial production, especially in biodiesel industry. |
| publisher |
BioMed Central |
| publishDate |
2016 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785665/ |
| _version_ |
1613549991771504640 |