Inhibition of hypoxia-inducible factor via upregulation of von Hippel-Lindau protein induces “angiogenic switch off” in a hepatoma mouse model

Inhibition of hypoxia-inducible factor via upregulation of von Hippel-Lindau protein induces “angiogenic switch off” in a hepatoma mouse model

“Angiogenic switch off” is one of the ideal therapeutic concepts in the treatment of cancer. However, the specific molecules which can induce “angiogenic switch off” in tumor have not been identified yet. In this study, we focused on von Hippel-Lindau protein (pVHL) in hepatocellular carcinoma (HCC)...

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Bibliographic Details
Main Authors: Iwamoto, Hideki, Nakamura, Toru, Koga, Hironori, Izaguirre-Carbonell, Jesus, Kamisuki, Shinji, Sugawara, Fumio, Abe, Mitsuhiko, Iwabata, Kazuki, Ikezono, Yu, Sakaue, Takahiko, Masuda, Atsutaka, Yano, Hirohisa, Ohta, Keisuke, Nakano, Masahito, Shimose, Shigeo, Shirono, Tomotake, Torimura, Takuji
Format: Online
Language:English
Published: Nature Publishing Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782957/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782957/

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