Imaging the accumulation and suppression of tau pathology using multiparametric MRI

Mouse models of Alzheimer's disease have served as valuable tools for investigating pathogenic mechanisms relating to neurodegeneration, including tau-mediated and neurofibrillary tangle pathology—a major hallmark of the disease. In this work, we have used multiparametric magnetic resonance ima...

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Bibliographic Details
Main Authors: Holmes, Holly E., Colgan, Niall, Ismail, Ozama, Ma, Da, Powell, Nick M., O'Callaghan, James M., Harrison, Ian F., Johnson, Ross A., Murray, Tracey K., Ahmed, Zeshan, Heggenes, Morton, Fisher, Alice, Cardoso, M.J., Modat, Marc, Walker-Samuel, Simon, Fisher, Elizabeth M.C., Ourselin, Sebastien, O'Neill, Michael J., Wells, Jack A., Collins, Emily C., Lythgoe, Mark F.
Format: Online
Language:English
Published: Elsevier 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782737/