The Curcumin Analog C-150, Influencing NF-κB, UPR and Akt/Notch Pathways Has Potent Anticancer Activity In Vitro and In Vivo

The Curcumin Analog C-150, Influencing NF-κB, UPR and Akt/Notch Pathways Has Potent Anticancer Activity In Vitro and In Vivo

C-150 a Mannich-type curcumin derivative, exhibited pronounced cytotoxic effects against eight glioma cell lines at micromolar concentrations. Inhibition of cell proliferation by C-150 was mediated by affecting multiple targets as confirmed at transcription and protein level. C-150 effectively reduc...

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Bibliographic Details
Main Authors: Hackler, László, Ózsvári, Béla, Gyuris, Márió, Sipos, Péter, Fábián, Gabriella, Molnár, Eszter, Marton, Annamária, Faragó, Nóra, Mihály, József, Nagy, Lajos István, Szénási, Tibor, Diron, Andrea, Párducz, Árpád, Kanizsai, Iván, Puskás, László G.
Format: Online
Language:English
Published: Public Library of Science 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778904/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778904/

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