Combined Use of Gene Expression Modeling and siRNA Screening Identifies Genes and Pathways Which Enhance the Activity of Cisplatin When Added at No Effect Levels to Non-Small Cell Lung Cancer Cells In Vitro

Combined Use of Gene Expression Modeling and siRNA Screening Identifies Genes and Pathways Which Enhance the Activity of Cisplatin When Added at No Effect Levels to Non-Small Cell Lung Cancer Cells In Vitro

Platinum-based combination chemotherapy is the standard treatment for advanced non-small cell lung cancer (NSCLC). While cisplatin is effective, its use is not curative and resistance often emerges. As a consequence of microenvironmental heterogeneity, many tumour cells are exposed to sub-lethal dos...

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Bibliographic Details
Main Authors: Leung, Ada W. Y., Hung, Stacy S., Backstrom, Ian, Ricaurte, Daniel, Kwok, Brian, Poon, Steven, McKinney, Steven, Segovia, Romulo, Rawji, Jenna, Qadir, Mohammed A., Aparicio, Samuel, Stirling, Peter C., Steidl, Christian, Bally, Marcel B.
Format: Online
Language:English
Published: Public Library of Science 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777418/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777418/

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