Modeling the pharmacokinetic‐pharmacodynamic relationship of the monoclonal anti‐macaque‐IL‐15 antibody Hu714MuXHu in cynomolgus monkeys

Modeling the pharmacokinetic‐pharmacodynamic relationship of the monoclonal anti‐macaque‐IL‐15 antibody Hu714MuXHu in cynomolgus monkeys

Hu714MuXHu is a recombinant chimeric murine‐human monoclonal antibody directed against interleukin‐15 (IL‐15), a proinflammatory cytokine associated with memory CD8+ and natural killer (NK) T‐cell activation and implicated in the pathogenesis of inflammatory diseases. A pharmacokinetic‐pharmacodynam...

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Bibliographic Details
Main Authors: Pan, Wei. J., Li, Hong, Xiao, Jim J., Horner, Michelle J., Lebrec, Herve N., Butz, Eric A., Kaliyaperumal, Arunan, Cheah, Tsui C., Ortiz, Robert C., Prokop, Samantha P., Buntich, Sabina A., Boren, Babette M., Wolford, Suzanne T., Tsuji, Wayne H., Wienkers, Larry C., Köck, Kathleen
Format: Online
Language:English
Published: John Wiley and Sons Inc. 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777250/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777250/

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