Novel O-linked methylated glycan antigens decorate secreted immunodominant glycoproteins from the intestinal nematode Heligmosomoides polygyrus

Novel O-linked methylated glycan antigens decorate secreted immunodominant glycoproteins from the intestinal nematode Heligmosomoides polygyrus

•Heligmosomoides polygyrus excretory–secretory (ES) proteins carry diverse N- and O-glycans, and many are O-methylated.•A methylhexose containing O-glycan of abundant ES glycoproteins is immunodominant.•This dominant glycan is not the immunomodulatory heat-stable ES component.

Bibliographic Details
Main Authors: Hewitson, James P., Nguyen, D. Linh, van Diepen, Angela, Smit, Cornelis H., Koeleman, Carolien A., McSorley, Henry J., Murray, Janice, Maizels, Rick M., Hokke, Cornelis H.
Format: Online
Language:English
Published: Elsevier Science 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776704/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776704/

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