SAMHD1 transcript upregulation during SIV infection of the central nervous system does not associate with reduced viral load

SAMHD1 transcript upregulation during SIV infection of the central nervous system does not associate with reduced viral load

Restriction of HIV-1 in myeloid-lineage cells is attributed in part to the nucleotidase activity of the SAM-domain and HD-domain containing protein (SAMHD1), which depletes free nucleotides, blocking reverse transcription. In the same cells, the Vpx protein of HIV-2 and most SIVs counteracts SAMHD1....

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Bibliographic Details
Main Authors: Buchanan, Erin L., Espinoza, Diego A., McAlexander, Melissa A., Myers, Stephanie L., Moyer, Adam, Witwer, Kenneth W.
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776177/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776177/

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