Small Molecule Inhibition of Ligand-Stimulated RAGE-DIAPH1 Signal Transduction

Small Molecule Inhibition of Ligand-Stimulated RAGE-DIAPH1 Signal Transduction

The receptor for advanced glycation endproducts (RAGE) binds diverse ligands linked to chronic inflammation and disease. NMR spectroscopy and x-ray crystallization studies of the extracellular domains of RAGE indicate that RAGE ligands bind by distinct charge- and hydrophobicity-dependent mechanisms...

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Bibliographic Details
Main Authors: Manigrasso, Michaele B., Pan, Jinhong, Rai, Vivek, Zhang, Jinghua, Reverdatto, Sergey, Quadri, Nosirudeen, DeVita, Robert J., Ramasamy, Ravichandran, Shekhtman, Alexander, Schmidt, Ann Marie
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776135/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776135/

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