Adjunctive Phosphodiesterase-4 Inhibitor Therapy Improves Antibiotic Response to Pulmonary Tuberculosis in a Rabbit Model

Adjunctive Phosphodiesterase-4 Inhibitor Therapy Improves Antibiotic Response to Pulmonary Tuberculosis in a Rabbit Model

•CC-11050 is an anti-inflammatory molecule targeting host phosphodiesterase-4.•CC-11050 plus isoniazid therapy significantly reduced bacillary load and pathology in a rabbit model pulmonary tuberculosis.•CC-11050 can be a promising candidate for adjunctive host directed therapy of patients with acti...

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Bibliographic Details
Main Authors: Subbian, Selvakumar, Tsenova, Liana, Holloway, Jennifer, Peixoto, Blas, O'Brien, Paul, Dartois, Véronique, Khetani, Vikram, Zeldis, Jerome B., Kaplan, Gilla
Format: Online
Language:English
Published: Elsevier 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776074/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776074/

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