Epigenetic modification of PKMζ rescues aging-related cognitive impairment

Epigenetic modification of PKMζ rescues aging-related cognitive impairment

Cognition is impacted by aging. However, the mechanisms that underlie aging-associated cognitive impairment are unclear. Here we showed that cognitive decline in aged rats was associated with changes in DNA methylation of protein kinase Mζ (PKMζ) in the prelimbic cortex (PrL). PKMζ is a crucial mole...

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Bibliographic Details
Main Authors: Chen, Chen, Meng, Shi-Qiu, Xue, Yan-Xue, Han, Ying, Sun, Cheng-Yu, Deng, Jia-Hui, Chen, Na, Bao, Yan-Ping, Zhang, Fei-Long, Cao, Lin-Lin, Zhu, Wei-Guo, Shi, Jie, Song, Wei-Hong, Lu, Lin
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772003/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772003/

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