The role of endoscopic ultrasound in pancreatic cancer screening

Pancreatic cancer (PC) is a highly lethal cancer. Despite a significant advancement in cancer treatment, the mortality rate of PC is nearly identical to the incidence rates. Early detection of tumor or its precursor lesions with dysplasia may be the most effective approach to improve survival. Scree...

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Main Authors:	Bhutani, Manoop S., Koduru, Pramoda, Joshi, Virendra, Saxena, Payal, Suzuki, Rei, Irisawa, Atsushi, Yamao, Kenji
Format:	Online
Language:	English
Published:	Medknow Publications & Media Pvt Ltd 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770628/

id	pubmed-4770628
recordtype	oai_dc
spelling	pubmed-47706282016-03-09 The role of endoscopic ultrasound in pancreatic cancer screening Bhutani, Manoop S. Koduru, Pramoda Joshi, Virendra Saxena, Payal Suzuki, Rei Irisawa, Atsushi Yamao, Kenji Review Article Pancreatic cancer (PC) is a highly lethal cancer. Despite a significant advancement in cancer treatment, the mortality rate of PC is nearly identical to the incidence rates. Early detection of tumor or its precursor lesions with dysplasia may be the most effective approach to improve survival. Screening strategies should include identification of the population at high risk of developing PC, and an intense application of screening tools with adequate sensitivity to detect PC at an early curable stage. Endoscopic ultrasound (EUS) and magnetic resonance imaging (MRI) seem to be the most promising modalities for PC screening based on the data so far. EUS had an additional advantage over MRI by being able to obtain tissue sample during the same examination. Several questions remain unanswered at this time regarding the age to begin screening, frequency of screening, management of asymptomatic pancreatic lesions detected on screening, timing of resection, and extent of surgery and impact of screening on survival. Novel techniques such as needle-based confocal laser endomicroscopy (nCLE), along with biomarkers, may be helpful to identify pancreatic lesions with more aggressive malignant potential. Further studies will hopefully lead to the development of strategies combining EUS with other technological/biological advancements that will be cost-effective and have an impact on survival. Medknow Publications & Media Pvt Ltd 2016 /pmc/articles/PMC4770628/ /pubmed/26879161 http://dx.doi.org/10.4103/2303-9027.175876 Text en Copyright: © 2016 Spring Media Publishing Co. Ltd http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Bhutani, Manoop S. Koduru, Pramoda Joshi, Virendra Saxena, Payal Suzuki, Rei Irisawa, Atsushi Yamao, Kenji
spellingShingle	Bhutani, Manoop S. Koduru, Pramoda Joshi, Virendra Saxena, Payal Suzuki, Rei Irisawa, Atsushi Yamao, Kenji The role of endoscopic ultrasound in pancreatic cancer screening
author_facet	Bhutani, Manoop S. Koduru, Pramoda Joshi, Virendra Saxena, Payal Suzuki, Rei Irisawa, Atsushi Yamao, Kenji
author_sort	Bhutani, Manoop S.
title	The role of endoscopic ultrasound in pancreatic cancer screening
title_short	The role of endoscopic ultrasound in pancreatic cancer screening
title_full	The role of endoscopic ultrasound in pancreatic cancer screening
title_fullStr	The role of endoscopic ultrasound in pancreatic cancer screening
title_full_unstemmed	The role of endoscopic ultrasound in pancreatic cancer screening
title_sort	role of endoscopic ultrasound in pancreatic cancer screening
description	Pancreatic cancer (PC) is a highly lethal cancer. Despite a significant advancement in cancer treatment, the mortality rate of PC is nearly identical to the incidence rates. Early detection of tumor or its precursor lesions with dysplasia may be the most effective approach to improve survival. Screening strategies should include identification of the population at high risk of developing PC, and an intense application of screening tools with adequate sensitivity to detect PC at an early curable stage. Endoscopic ultrasound (EUS) and magnetic resonance imaging (MRI) seem to be the most promising modalities for PC screening based on the data so far. EUS had an additional advantage over MRI by being able to obtain tissue sample during the same examination. Several questions remain unanswered at this time regarding the age to begin screening, frequency of screening, management of asymptomatic pancreatic lesions detected on screening, timing of resection, and extent of surgery and impact of screening on survival. Novel techniques such as needle-based confocal laser endomicroscopy (nCLE), along with biomarkers, may be helpful to identify pancreatic lesions with more aggressive malignant potential. Further studies will hopefully lead to the development of strategies combining EUS with other technological/biological advancements that will be cost-effective and have an impact on survival.
publisher	Medknow Publications & Media Pvt Ltd
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770628/
_version_	1613544592770072576

The role of endoscopic ultrasound in pancreatic cancer screening

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