Specifically modified Env immunogens activate B-cell precursors of broadly neutralizing HIV-1 antibodies in transgenic mice

Specifically modified Env immunogens activate B-cell precursors of broadly neutralizing HIV-1 antibodies in transgenic mice

VRC01-class broadly neutralizing HIV-1 antibodies protect animals from experimental infection and could contribute to an effective vaccine response. Their predicted germline forms (gl) bind Env inefficiently, which may explain why they are not elicited by HIV-1 Env-immunization. Here we show that an...

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Bibliographic Details
Main Authors: McGuire, Andrew T., Gray, Matthew D., Dosenovic, Pia, Gitlin, Alexander D., Freund, Natalia T., Petersen, John, Correnti, Colin, Johnsen, William, Kegel, Robert, Stuart, Andrew B., Glenn, Jolene, Seaman, Michael S., Schief, William R., Strong, Roland K., Nussenzweig, Michel C., Stamatatos, Leonidas
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770077/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770077/

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