TGF-β blockade depletes T regulatory cells from metastatic pancreatic tumors in a vaccine dependent manner

TGF-β blockade depletes T regulatory cells from metastatic pancreatic tumors in a vaccine dependent manner

Our neoadjuvant clinical trial of a GM-CSF secreting allogeneic pancreas tumor vaccine (GVAX) revealed the development of tertiary lymphoid aggregates (TLAs) within the pancreatic ductal adenocarcinoma (PDA) tumor microenvironment 2 weeks after GVAX treatment. Microarray studies revealed that multip...

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Bibliographic Details
Main Authors: Soares, Kevin C., Rucki, Agnieszka A., Kim, Victoria, Foley, Kelly, Solt, Sara, Wolfgang, Christopher L., Jaffee, Elizabeth M., Zheng, Lei
Format: Online
Language:English
Published: Impact Journals LLC 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767487/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767487/

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