Open Sesame: treasure in store-operated calcium entry pathway for cancer therapy
Store-operated Ca2+ entry (SOCE) controls intracellular Ca2+ homeostasis and regulates a wide range of cellular events including proliferation, migration and invasion. The discovery of STIM proteins as Ca2+ sensors and Orai proteins as Ca2+ channel pore forming units provided molecular tools to unde...
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| Format: | Online |
| Language: | English |
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2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765918/ |
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pubmed-4765918 |
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pubmed-47659182016-02-24 Open Sesame: treasure in store-operated calcium entry pathway for cancer therapy Zui, PAN JianJie, MA Article Store-operated Ca2+ entry (SOCE) controls intracellular Ca2+ homeostasis and regulates a wide range of cellular events including proliferation, migration and invasion. The discovery of STIM proteins as Ca2+ sensors and Orai proteins as Ca2+ channel pore forming units provided molecular tools to understand the physiological function of SOCE. Many studies have revealed the pathophysiological roles of Orai and STIM in tumor cells. This review focuses on recent advances in SOCE and its contribution to tumorigenesis. Altered Orai and/or STIM functions may serve as biomarkers for cancer prognosis, and targeting the SOCE pathway may provide a novel means for cancer treatment. 2014-12-07 2015-01 /pmc/articles/PMC4765918/ /pubmed/25481035 http://dx.doi.org/10.1007/s11427-014-4774-3 Text en http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Zui, PAN JianJie, MA |
| spellingShingle |
Zui, PAN JianJie, MA Open Sesame: treasure in store-operated calcium entry pathway for cancer therapy |
| author_facet |
Zui, PAN JianJie, MA |
| author_sort |
Zui, PAN |
| title |
Open Sesame: treasure in store-operated calcium entry pathway for cancer therapy |
| title_short |
Open Sesame: treasure in store-operated calcium entry pathway for cancer therapy |
| title_full |
Open Sesame: treasure in store-operated calcium entry pathway for cancer therapy |
| title_fullStr |
Open Sesame: treasure in store-operated calcium entry pathway for cancer therapy |
| title_full_unstemmed |
Open Sesame: treasure in store-operated calcium entry pathway for cancer therapy |
| title_sort |
open sesame: treasure in store-operated calcium entry pathway for cancer therapy |
| description |
Store-operated Ca2+ entry (SOCE) controls intracellular Ca2+ homeostasis and regulates a wide range of cellular events including proliferation, migration and invasion. The discovery of STIM proteins as Ca2+ sensors and Orai proteins as Ca2+ channel pore forming units provided molecular tools to understand the physiological function of SOCE. Many studies have revealed the pathophysiological roles of Orai and STIM in tumor cells. This review focuses on recent advances in SOCE and its contribution to tumorigenesis. Altered Orai and/or STIM functions may serve as biomarkers for cancer prognosis, and targeting the SOCE pathway may provide a novel means for cancer treatment. |
| publishDate |
2014 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765918/ |
| _version_ |
1613542831418245120 |