Intracardiac Thrombosis in Sickle Cell Disease
In patients with sickle cell disease, thrombotic microangiopathy is a rare complication. Also in sickle cell disease, intracardiac thrombus formation without structural heart diseases or atrial arrhythmias is a rare phenomenon. We herein describe a 22-year-old woman, who was a known case of sickle c...
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Iranian Journal of Medical Sciences
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764966/ |
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pubmed-47649662016-03-17 Intracardiac Thrombosis in Sickle Cell Disease Nikparvar, Marzieh Evazi, Mohammad Reza Eftekhari, Tasnim Moosavi, Farzaneh Case Report In patients with sickle cell disease, thrombotic microangiopathy is a rare complication. Also in sickle cell disease, intracardiac thrombus formation without structural heart diseases or atrial arrhythmias is a rare phenomenon. We herein describe a 22-year-old woman, who was a known case of sickle cell-βthalassemia, had a history of recent missed abortion, and was admitted with a vaso-occlusive crisis. The patient had manifestations of microangiopathic hemolytic anemia, including laboratory evidence of hemolytic anemia, thrombocytopenia, respiratory distress, fever, jaundice, and abnormal liver function and coagulation tests, accompanied by clot formation on the Eustachian valve of the inferior vena cava in the right atrium and also a long and worm-like thrombus in the right ventricle. Therapeutic plasma exchange improved her clinical condition, and her intracardiac thrombus was completely resolved after 1 week. Echocardiography, as a simple and inexpensive imaging modality, had a significant role in the diagnosis and follow-up of this patient. Iranian Journal of Medical Sciences 2016-03 /pmc/articles/PMC4764966/ /pubmed/26989287 Text en Copyright: © Iranian Journal of Medical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Nikparvar, Marzieh Evazi, Mohammad Reza Eftekhari, Tasnim Moosavi, Farzaneh |
| spellingShingle |
Nikparvar, Marzieh Evazi, Mohammad Reza Eftekhari, Tasnim Moosavi, Farzaneh Intracardiac Thrombosis in Sickle Cell Disease |
| author_facet |
Nikparvar, Marzieh Evazi, Mohammad Reza Eftekhari, Tasnim Moosavi, Farzaneh |
| author_sort |
Nikparvar, Marzieh |
| title |
Intracardiac Thrombosis in Sickle Cell Disease |
| title_short |
Intracardiac Thrombosis in Sickle Cell Disease |
| title_full |
Intracardiac Thrombosis in Sickle Cell Disease |
| title_fullStr |
Intracardiac Thrombosis in Sickle Cell Disease |
| title_full_unstemmed |
Intracardiac Thrombosis in Sickle Cell Disease |
| title_sort |
intracardiac thrombosis in sickle cell disease |
| description |
In patients with sickle cell disease, thrombotic microangiopathy is a rare complication. Also in sickle cell disease, intracardiac thrombus formation without structural heart diseases or atrial arrhythmias is a rare phenomenon. We herein describe a 22-year-old woman, who was a known case of sickle cell-βthalassemia, had a history of recent missed abortion, and was admitted with a vaso-occlusive crisis. The patient had manifestations of microangiopathic hemolytic anemia, including laboratory evidence of hemolytic anemia, thrombocytopenia, respiratory distress, fever, jaundice, and abnormal liver function and coagulation tests, accompanied by clot formation on the Eustachian valve of the inferior vena cava in the right atrium and also a long and worm-like thrombus in the right ventricle. Therapeutic plasma exchange improved her clinical condition, and her intracardiac thrombus was completely resolved after 1 week. Echocardiography, as a simple and inexpensive imaging modality, had a significant role in the diagnosis and follow-up of this patient. |
| publisher |
Iranian Journal of Medical Sciences |
| publishDate |
2016 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764966/ |
| _version_ |
1613542534900875264 |