Impaired theta-gamma coupling in APP-deficient mice

Amyloid precursor protein (APP) is critically involved in the pathophysiology of Alzheimer’s disease, but its physiological functions remain elusive. Importantly, APP knockout (APP-KO) mice exhibit cognitive deficits, suggesting that APP plays a role at the neuronal network level. To investigate thi...

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Bibliographic Details
Main Authors: Zhang, Xiaomin, Zhong, Wewei, Brankačk, Jurij, Weyer, Sascha W., Müller, Ulrike C., Tort, Adriano B. L., Draguhn, Andreas
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764939/