DDX5 and its associated lncRNA Rmrp modulate Th17 cell effector functions

DDX5 and its associated lncRNA Rmrp modulate Th17 cell effector functions

Th17 lymphocytes protect mucosal barriers from infections, but also contribute to multiple chronic inflammatory diseases. Their differentiation is controlled by RORγt, a ligand-regulated nuclear receptor. We identified the DEAD-box RNA helicase DDX5 as a RORγt partner that coordinates transcription...

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Bibliographic Details
Main Authors: Huang, Wendy, Thomas, Benjamin, Flynn, Ryan A., Gavzy, Samuel J., Wu, Lin, Kim, Sangwon V., Hall, Jason A., Miraldi, Emily R., Ng, Charles P., Rigo, Frank, Meadows, Sarah, Montoya, Nina R., Herrera, Natalia G., Domingos, Ana I., Rastinejad, Fraydoon, Myers, Richard M., Fuller-Pace, Frances V., Bonneau, Richard, Chang, Howard Y., Acuto, Oreste, Littman, Dan R.
Format: Online
Language:English
Published: 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4762670/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4762670/

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