Neural Basis of Anhedonia and Amotivation in Patients with Schizophrenia: The role of Reward System

Anhedonia, the inability to feel pleasure, and amotivation, the lack of motivation, are two prominent negative symptoms of schizophrenia, which contribute to the poor social and occupational behaviors in the patients. Recently growing evidence shows that anhedonia and amotivation are tied together,...

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Main Authors:	Lee, Jung Suk, Jung, Suwon, Park, Il Ho, Kim, Jae-Jin
Format:	Online
Language:	English
Published:	Bentham Science Publishers 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759314/

id	pubmed-4759314
recordtype	oai_dc
spelling	pubmed-47593142016-06-01 Neural Basis of Anhedonia and Amotivation in Patients with Schizophrenia: The role of Reward System Lee, Jung Suk Jung, Suwon Park, Il Ho Kim, Jae-Jin Article Anhedonia, the inability to feel pleasure, and amotivation, the lack of motivation, are two prominent negative symptoms of schizophrenia, which contribute to the poor social and occupational behaviors in the patients. Recently growing evidence shows that anhedonia and amotivation are tied together, but have distinct neural correlates. It is important to note that both of these symptoms may derive from deficient functioning of the reward network. A further analysis into the neuroimaging findings of schizophrenia shows that the neural correlates overlap in the reward network including the ventral striatum, anterior cingulate cortex and orbitofrontal cortex. Other neuroimaging studies have demonstrated the involvement of the default mode network in anhedonia. The identification of a specific deficit in hedonic and motivational capacity may help to elucidate the mechanisms behind social functioning deficits in schizophrenia, and may also lead to more targeted treatment of negative symptoms. Bentham Science Publishers 2015-12 2015-12 /pmc/articles/PMC4759314/ /pubmed/26630955 http://dx.doi.org/10.2174/1570159X13666150612230333 Text en ©2015 Bentham Science Publishers https://creativecommons.org/licenses/by-nc/4.0/legalcode This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Lee, Jung Suk Jung, Suwon Park, Il Ho Kim, Jae-Jin
spellingShingle	Lee, Jung Suk Jung, Suwon Park, Il Ho Kim, Jae-Jin Neural Basis of Anhedonia and Amotivation in Patients with Schizophrenia: The role of Reward System
author_facet	Lee, Jung Suk Jung, Suwon Park, Il Ho Kim, Jae-Jin
author_sort	Lee, Jung Suk
title	Neural Basis of Anhedonia and Amotivation in Patients with Schizophrenia: The role of Reward System
title_short	Neural Basis of Anhedonia and Amotivation in Patients with Schizophrenia: The role of Reward System
title_full	Neural Basis of Anhedonia and Amotivation in Patients with Schizophrenia: The role of Reward System
title_fullStr	Neural Basis of Anhedonia and Amotivation in Patients with Schizophrenia: The role of Reward System
title_full_unstemmed	Neural Basis of Anhedonia and Amotivation in Patients with Schizophrenia: The role of Reward System
title_sort	neural basis of anhedonia and amotivation in patients with schizophrenia: the role of reward system
description	Anhedonia, the inability to feel pleasure, and amotivation, the lack of motivation, are two prominent negative symptoms of schizophrenia, which contribute to the poor social and occupational behaviors in the patients. Recently growing evidence shows that anhedonia and amotivation are tied together, but have distinct neural correlates. It is important to note that both of these symptoms may derive from deficient functioning of the reward network. A further analysis into the neuroimaging findings of schizophrenia shows that the neural correlates overlap in the reward network including the ventral striatum, anterior cingulate cortex and orbitofrontal cortex. Other neuroimaging studies have demonstrated the involvement of the default mode network in anhedonia. The identification of a specific deficit in hedonic and motivational capacity may help to elucidate the mechanisms behind social functioning deficits in schizophrenia, and may also lead to more targeted treatment of negative symptoms.
publisher	Bentham Science Publishers
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759314/
_version_	1613540619513233408

Neural Basis of Anhedonia and Amotivation in Patients with Schizophrenia: The role of Reward System

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