Layer specific and general requirements for ERK/MAPK signaling in the developing neocortex

Aberrant signaling through the Raf/MEK/ERK (ERK/MAPK) pathway causes pathology in a family of neurodevelopmental disorders known as 'RASopathies' and is implicated in autism pathogenesis. Here, we have determined the functions of ERK/MAPK signaling in developing neocortical excitatory neur...

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Bibliographic Details
Main Authors: Xing, Lei, Larsen, Rylan S, Bjorklund, George Reed, Li, Xiaoyan, Wu, Yaohong, Philpot, Benjamin D, Snider, William D, Newbern, Jason M
Format: Online
Language:English
Published: eLife Sciences Publications, Ltd 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4758957/