Monitoring cancer stem cells: insights into clinical oncology

Cancer stem cells (CSCs) are a small, characteristically distinctive subset of tumor cells responsible for tumor initiation and progression. Several treatment modalities, such as surgery, glycolytic inhibition, driving CSC proliferation, immunotherapy, and hypofractionated radiotherapy, may have the...

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Main Authors:	Lin, ShuChen, Xu, YingChun, Gan, ZhiHua, Han, Kun, Hu, HaiYan, Yao, Yang, Huang, MingZhu, Min, DaLiu
Format:	Online
Language:	English
Published:	Dove Medical Press 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755432/

id	pubmed-4755432
recordtype	oai_dc
spelling	pubmed-47554322016-02-29 Monitoring cancer stem cells: insights into clinical oncology Lin, ShuChen Xu, YingChun Gan, ZhiHua Han, Kun Hu, HaiYan Yao, Yang Huang, MingZhu Min, DaLiu Perspectives Cancer stem cells (CSCs) are a small, characteristically distinctive subset of tumor cells responsible for tumor initiation and progression. Several treatment modalities, such as surgery, glycolytic inhibition, driving CSC proliferation, immunotherapy, and hypofractionated radiotherapy, may have the potential to eradicate CSCs. We propose that monitoring CSCs is important in clinical oncology as CSC populations may reflect true treatment response and assist with managing treatment strategies, such as defining optimal chemotherapy cycles, permitting pretreatment cancer surveillance, conducting a comprehensive treatment plan, modifying radiation treatment, and deploying rechallenge chemotherapy. Then, we describe methods for monitoring CSCs. Dove Medical Press 2016-02-11 /pmc/articles/PMC4755432/ /pubmed/26929644 http://dx.doi.org/10.2147/OTT.S96645 Text en © 2016 Lin et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Lin, ShuChen Xu, YingChun Gan, ZhiHua Han, Kun Hu, HaiYan Yao, Yang Huang, MingZhu Min, DaLiu
spellingShingle	Lin, ShuChen Xu, YingChun Gan, ZhiHua Han, Kun Hu, HaiYan Yao, Yang Huang, MingZhu Min, DaLiu Monitoring cancer stem cells: insights into clinical oncology
author_facet	Lin, ShuChen Xu, YingChun Gan, ZhiHua Han, Kun Hu, HaiYan Yao, Yang Huang, MingZhu Min, DaLiu
author_sort	Lin, ShuChen
title	Monitoring cancer stem cells: insights into clinical oncology
title_short	Monitoring cancer stem cells: insights into clinical oncology
title_full	Monitoring cancer stem cells: insights into clinical oncology
title_fullStr	Monitoring cancer stem cells: insights into clinical oncology
title_full_unstemmed	Monitoring cancer stem cells: insights into clinical oncology
title_sort	monitoring cancer stem cells: insights into clinical oncology
description	Cancer stem cells (CSCs) are a small, characteristically distinctive subset of tumor cells responsible for tumor initiation and progression. Several treatment modalities, such as surgery, glycolytic inhibition, driving CSC proliferation, immunotherapy, and hypofractionated radiotherapy, may have the potential to eradicate CSCs. We propose that monitoring CSCs is important in clinical oncology as CSC populations may reflect true treatment response and assist with managing treatment strategies, such as defining optimal chemotherapy cycles, permitting pretreatment cancer surveillance, conducting a comprehensive treatment plan, modifying radiation treatment, and deploying rechallenge chemotherapy. Then, we describe methods for monitoring CSCs.
publisher	Dove Medical Press
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755432/
_version_	1613539302727221248

Monitoring cancer stem cells: insights into clinical oncology

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